کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9425845 | 1295895 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chronic restraint stress down-regulates amygdaloid expression of polysialylated neural cell adhesion molecule
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
LaDLPSA-NCAMCelCEMtPATBSCRSCECChronic stress - استرس مزمنChronic restraint stress - استرس مهلک مزمنAnxiety - اضطرابphosphate buffer - بافر فسفاتanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceFear - ترسTris-buffered saline - تریس بافر شورtissue plasminogen activator - فعال کننده بافتی پلاسمینوژنSubstance P - ماده Pbasolateral complex of the amygdala - مجتمع نازک امیگدالpolysialylated neural cell adhesion molecule - مولکول چسبندگی سلولی عصبی پلیسیسیله شدهcentral amygdaloid nucleus - هسته مرکزی amygdaloidmedial amygdaloid nucleus - هسته مرکزی آمیگدولیدHippocampus - هیپوکامپ Synaptic plasticity - پلاستیسیته سیناپسیoptical density - چگالی نوریGlucocorticoids - گلوکوکورتیکوئیدها
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The amygdala is a brain area which plays a decisive role in fear and anxiety. Since exposure to chronic stress can induce profound effects in emotion and cognition, plasticity in specific amygdaloid nuclei in response to prior stress has been hypothesized to account for stress-induced emotional alterations. In order to identify amygdala nuclei which may be affected under chronic stress conditions we evaluated the effects of 21-days chronic restraint stress on the expression of a molecule implicated crucially in alterations in structural plasticity: the polysialylated neural cell adhesion molecule. We found that polysialylated neural cell adhesion molecule-immunoreactivity within the amygdala, present in somata and neuronal processes, has a regional gradient with the central medial and medial amygdaloid nuclei showing the highest levels. Our results demonstrate that chronic restraint stress induced an overall reduction in polysialylated neural cell adhesion molecule-immunoreactivity in the amygdaloid complex, mainly due to a significant decrease in the central medial amygdaloid and medial amygdaloid nuclei. Our data suggest that polysialylated neural cell adhesion molecule in these nuclei may play a prominent role in functional and structural remodeling induced by stress, being a potential mechanism for cognitive and emotional modulation. Furthermore, these finding provide the first clear evidence that life experiences can regulate the expression of polysialylated neural cell adhesion molecule in the amygdaloid complex.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 133, Issue 4, 2005, Pages 903-910
Journal: Neuroscience - Volume 133, Issue 4, 2005, Pages 903-910
نویسندگان
M.I. Cordero, J.J. RodrÃguez, H.A. Davies, C.J. Peddie, C. Sandi, M.G. Stewart,