کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9426038 | 1295905 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Early amygdala damage disrupts performance on medial prefrontal cortex-related tasks but spares spatial learning and memory in the rat
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کلمات کلیدی
PBSHPCAMXBLANACAmygdala lesionMPFCvmPFCAmygdala - آمیگدال، بادامهNeurodevelopmental disorders - اختلالات عصبی توسعهmediodorsal thalamus - تالاموس Medidorsalanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancepostnatal day - روز پس از زایمانSham - شامNeonatal lesion - ضایعه نوزادanterior–posterior - قدامی-خلفیVentral medial prefrontal cortex - قشر غده فوق کلیهmedial prefrontal cortex - قشر غده پروسترولPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریRat - موش صحراییmedial–lateral - میانی - جانبیNucleus accumbens - هسته accumbensbasolateral nucleus of the amygdala - هسته نزولی amygdalaHippocampus - هیپوکامپ dorsal–ventral - پشت و شکمی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Recent studies have demonstrated that the postnatal development of connections between the basolateral amygdala (BLA) and the medial prefrontal cortex (mPFC) mature around postnatal days 13-15 (pd13-15), whereas these between the BLA and other structures such as the nucleus accumbens and the mediodorsal thalamus are completed by pd7. Accordingly, it is hypothesized that mPFC cytoarchitecture and hence its function may be specifically affected by neonatal (i.e. on pd7) but not later induced (i.e. on pd21) damage to the BLA. To test this hypothesis, rats received excitotoxic lesions to the BLA on either pd7 or pd21 and were subjected to two tests putatively sensitive to mPFC dysfunction, namely food hoarding and spontaneous alternation. In addition, rats were tested for spatial learning and memory, to determine any possible effects on hippocampal function. Consistent with the documented effects of mPFC lesions, pd7 damage to the BLA impaired spontaneous alternation and food hoarding performance, an effect that was not found in rats with BLA lesions induced on pd21. Spatial learning and memory, however, were not affected by the (neonatal) lesion procedure. Together, these results indicate that neonatal BLA damage affects species-specific sequential behavior and flexibility, which may be attributed to abnormal functioning of the mPFC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 130, Issue 3, 2005, Pages 581-590
Journal: Neuroscience - Volume 130, Issue 3, 2005, Pages 581-590
نویسندگان
L. Diergaarde, M.A.F.M. Gerrits, J.P.W. Brouwers, J.M. van Ree,