کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9426586 | 1295927 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ethanol modulates the expression of GABAB receptor mRNAs in the prenatal rat brain in an age and area dependent manner
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
mRNASSCDEPCRPAgestational daysRNAse protection assay - آزمون حفاظت RNAseEthanol - اتانولThalamus - تالاموسdiethyl pyrocarbonate - دیورتیک پریکو کربناتDevelopment - رشدsodium chloride-sodium citrate - سدیم کلرید سدیم سیتراتbasal ganglia - عقدههای قاعدهایCortex - قشرcerebral cortex - قشر مغزCerebellum - مخچهbrain area - منطقه مغزMidbrain - میانمغز، مزانسفالHippocampus - هیپوکامپ GABAB receptors - گیرنده های GABAB
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Prenatal ethanol exposure has various deleterious effects on neuronal development. As GABAB receptor is known to play an important role during the development of the CNS, we now focused on its mRNA expression pattern in the rat brain during the late gestational days (GD) from 15.5 to GD 21.5. Ethanol's effect was also observed from GD 11.5 to GD 21.5. GABAB1 receptor mRNA showed a high expression level in GD 15.5 and 19.5, while GABAB2 receptor mRNA did in GD 15.5 and 21.5. The mRNAs levels depended on age and area during development. Ethanol exposure decreased GABAB1 receptor from GD 11.5 to GD 19.5 with slight increases in GD 21.5. The decreasing effects were area dependent, with the highest effects in the forebrain including cortex, whereas slight effects were observed in the midbrain and hindbrain. The present results suggest an important role of GABAB receptor in the effects of ethanol on prenatal brain developmental processes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 134, Issue 3, 2005, Pages 857-866
Journal: Neuroscience - Volume 134, Issue 3, 2005, Pages 857-866
نویسندگان
S.P. Li, J.H. Kim, M.S. Park, J.Y. Bahk, B.C. Chung, M.O. Kim,