کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9428953 | 1297020 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Methamphetamine is a highly addictive drug that has a neurotoxic effect on the brain. A growing body of evidence suggests that brain-derived neurotrophic factor (BDNF) is associated with addictive behavior. The present study investigated the changes in plasma BDNF concentration that were induced by chronic methamphetamine use. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in methamphetamine users and in a control group. The plasma BDNF concentrations of methamphetamine users were significantly higher compared with those of controls (2536.3Â pg/ml versus 1352.6Â pg/ml). This finding suggests that BDNF plays some role in the neurotoxicity of methamphetamine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 388, Issue 2, 11 November 2005, Pages 112-115
Journal: Neuroscience Letters - Volume 388, Issue 2, 11 November 2005, Pages 112-115
نویسندگان
Dai-Jin Kim, Sungwon Roh, Yujung Kim, Su-Jung Yoon, Hae-Kook Lee, Chang-Su Han, Yong-Ku Kim,