کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9429425 | 1615205 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Localization of the Nav1.8 sodium channel isoform at nodes of Ranvier in normal human radicular tooth pulp
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Localization of the Nav1.8 sodium channel isoform at nodes of Ranvier in normal human radicular tooth pulp Localization of the Nav1.8 sodium channel isoform at nodes of Ranvier in normal human radicular tooth pulp](/preview/png/9429425.png)
چکیده انگلیسی
The activation of voltage-gated sodium channels is necessary for action potential propagation and multiple sodium channel isoforms have been identified that show a differential distribution throughout the nervous system. An evaluation of sodium channel localization in the radicular pulp from normal human extracted third molars established the presence of the Nav1.8 isoform at nodes of Ranvier in a subpopulation of the myelinated axons as demonstrated with immunofluorescence confocal microscopy. A caspr antibody was used to identify the paranodal region of nodes of Ranvier and quantitative analysis revealed that 16.5% of the nodes contained significant Nav1.8 immunoreactivity. Since the Nav1.6 isoform has been described as the predominant sodium channel at essentially all nodes, the finding of Nav1.8 in a subpopulation of nodes suggests that multiple isoforms may coexist at some nodes of Ranvier and also suggests that this isoform may be an important nodal sodium channel type in the peripheral sensory nervous system of humans.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 380, Issues 1â2, 20â27 May 2005, Pages 32-36
Journal: Neuroscience Letters - Volume 380, Issues 1â2, 20â27 May 2005, Pages 32-36
نویسندگان
Michael A. Henry, Howard J. Sorensen, Lonnie R. Johnson, S. Rock Levinson,