کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9436643 1615695 2005 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synaptic transmission mediated by ionotropic glutamate, glycine and GABA receptors in the rat's ventral nucleus of the lateral lemniscus
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های حسی
پیش نمایش صفحه اول مقاله
Synaptic transmission mediated by ionotropic glutamate, glycine and GABA receptors in the rat's ventral nucleus of the lateral lemniscus
چکیده انگلیسی
The synaptic pharmacology of the ventral nucleus of the lateral lemniscus (VNLL) was investigated in brain slices obtained from rats of 14-37 days old using intracellular recording techniques. Excitatory and inhibitory synaptic potentials (EPSPs and IPSPs) were elicited by electrical stimulation of the lemniscal pathway and recorded from neurons with five types of intrinsic firing patterns (onset, pause, adapting, regular and bursting types). Synaptic receptors that mediated the EPSPs and IPSPs were identified using AMPA, NMDA, GABAA and glycine receptor antagonists. The early/short EPSPs were mediated by AMPA receptors. The late/long EPSPs, encountered only in neurons of younger animals, were mediated by NMDA receptors. The IPSPs in most neurons were mediated by glycine receptors. In some neurons the IPSPs were mediated by GABAA receptors or both glycine and GABAA receptors. The temporal dynamics of fast AMPA EPSPs and glycinergic IPSPs were very similar. AMPA EPSPs and glycinergic (and/or GABAergic) IPSPs could be encountered in a single neuron. The results suggest that the VNLL not only relays incoming signals rapidly from the lower brainstem to the inferior colliculus, but also integrates excitatory and inhibitory inputs to modify and process auditory information.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 203, Issues 1–2, May 2005, Pages 159-171
نویسندگان
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