کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9471099 1320067 2005 21 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Parameter estimation in a stochastic model of the tubuloglomerular feedback mechanism in a rat nephron
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Parameter estimation in a stochastic model of the tubuloglomerular feedback mechanism in a rat nephron
چکیده انگلیسی
To estimate the key parameters of the model we have developed a new estimation method based on the oscillatory behavior of the data. The dynamics is characterized by the spectral density, which has been estimated for the observed time series, and numerically approximated for the model. The parameters have then been estimated by the least squares distance between data and model spectral densities. To evaluate the estimation procedure measurements of the proximal tubular pressure from 35 nephrons in 16 rat kidneys have been analyzed, and the parameters characterizing the gain and the delay have been estimated. There was good agreement between the estimated values, and the values obtained for the same parameters in independent, previously published experiments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mathematical Biosciences - Volume 194, Issue 1, March 2005, Pages 49-69
نویسندگان
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