Multidrug resistance reversal agent from Jatropha elliptica

Bioassay-guided fractionation of Jatropha elliptica extract led to 2,6-dimethyl-4-phenyl-pyridine-3,5-dicarboxylic acid diethyl ester (8). This compound acts as an inhibitor of the NorA efflux pump found in a multidrug resistant strain of Staphylococcus aureus.