Steryl epoxide, secobutanolide and butanolides from the stem wood of Machilus zuihoensis

The dimeric steryl epoxide, machillene (1), the secobutanolide, secomahubanolide (2), and two butanolides, zuihoenalide (3), and 3-(1-methoxyoctadecyl)-5-methylene-5H-furan-2-one (4), together with 12 known compounds, have been isolated from the stem wood of Machilus zuihoensis. Their structures were determined by means of spectroscopic analyses. Machillene (1) showed cytotoxic activity against NUGC-3 and HONE-1 cancer cell lines in vitro.