An efficient strategy for the preparation of one-bead-one-peptide libraries on a new biocompatible solid support

A new strategy for the preparation of one-bead-one-peptide libraries compatible with solid-phase screening and subsequent detachment of the peptide from the resin for sequence determination by MS/MS is described. The method is based on the use of ChemMatrix, a new, fully PEG-based resin, together with 4-hydroxymethylbenzoic acid linker.