کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9591204 | 1507010 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Geometrical isomerism and conformational charges of selected open-ring enaminones in its neutral and protonated forms
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی تئوریک و عملی
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چکیده انگلیسی
Enaminones are chemical compounds consisting of an amino group linked through a CC to a carbonyl group. They combine the ambident nucleophility of enamines with the ambident electrophility of enones. Open-ring enaminones probed to be excellent prodrugs of model primary amines because their transportation ability trough biological membranes, while some cyclic enaminones have been reported as effective anti-epiletic agents. Selected open-ring enaminones, has been subjected to quantum chemical studies with the assumption that their flexibility wills allow more precise complexation with the corresponding receptor. Various conformers were investigated in a search for structural coincidences with the anti-convulsants cyclic enaminones.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure: THEOCHEM - Volume 725, Issues 1â3, 11 July 2005, Pages 63-68
Journal: Journal of Molecular Structure: THEOCHEM - Volume 725, Issues 1â3, 11 July 2005, Pages 63-68
نویسندگان
Juan C. Garro MartÃnez, Graciela N. Zamarbide, Mario R. Estrada, Eduardo A. Castro,