کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9605544 | 44166 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Study on spectroscopic characterization of meso-tetrakis (4-hydroxyphenyl) porphyrin (THPP) in β-cyclodextrin and its derivatives
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
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چکیده انگلیسی
Meso-Tetrakis (4-hydroxylphenyl) porphyrin (THPP) is a photosensitize offering an alternate approach to the treatment of cancer in the form of photodynamic therapy (PDT). The supramolecular system of THPP and β-cyclodextrin (β-CD), hydroxypropyl-β-cyclodextrin (HP-β-CD) and carboxymethyl-β-cyclodextrin (CM-β-CD), in aqueous solution has been studied by fluorescence and UV-vis spectroscopy. The formation of inclusion complexes has been observed on the base of change of spectroscopy properties. It is noted that the addition of HP-β-CD leads to remarkably strong enhancement of fluorescence intensity (nearly 300 times) of THPP. THPP forms 1:1 inclusion complex with β-CD and 1:2 inclusion complexes with the two other derivatives. Comparative to β-CD and CM-β-CD, the strongest inclusion ability of HP-β-CD can be explained that the hydrogen bond plays significant role in the inclusion process. In addition, the UV-vis experimental showed that the cavity of HP-β-CD causes the transform of the state of THPP, which is in agreement with the effect of polarity of solvent. Comparative to the pure buffer solution, the distinct equilibrium, H4THPP2+âH2THPP, has been observed in the solution of HP-β-CD. It is certain that the enhancement factor of nearly 300 of fluorescence presents a potential application in the detection of THPP in pharmacokinetics and biodistribution studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 173, Issue 3, 15 July 2005, Pages 258-263
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 173, Issue 3, 15 July 2005, Pages 258-263
نویسندگان
Xiliang Guo, Wenting An, Shaomin Shuang, Fangqin Cheng, Chuan Dong,