Experimental and theoretical analysis of Friedel-Crafts acylation of thioanisole to 4-(methylthio)acetophenone using solid acids

Experimental and theoretical analysis of selective acylation of thioanisole with acetic anhydride to 4-(methylthio)acetophenone was performed with Amberlyst-15, which was the best catalyst vis-a-vis 20% w/w Cs-DTP/K-10 (clay supported heteropolyacid), Indion-190 and Indion-130.