کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9690488 1457241 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protein separation using ultrafiltration - an example of multi-scale complex systems
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی جریان سیال و فرایندهای انتقال
پیش نمایش صفحه اول مقاله
Protein separation using ultrafiltration - an example of multi-scale complex systems
چکیده انگلیسی
In this mini-review, the complexity of protein fractionation using ultrafiltration is discussed. The coupling of the system hydrodynamics, boundary layer transport, membrane permeation, electrostatic and hydrophobic interactions and its effects on protein transmission and membrane selectivity are analysed. Although ultrafiltration is promising for larger scale protein purification and also with outstanding advantages both technically and economically, much needs to be done to derive the general guidance for membrane selection, process design and system operation. With fine tuning of operational and physiochemical conditions, the process can be greatly improved in terms of process productivity and protein purity. A coupled multi-scale approach might provide a way forward to analyse this complex system and improve the confidence in applying such a promising technology and predictability of the outcome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: China Particuology - Volume 3, Issue 6, December 2005, Pages 343-348
نویسندگان
,