کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
97366 160490 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Death of a female cocaine user due to the serotonin syndrome following moclobemide–venlafaxine overdose
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Death of a female cocaine user due to the serotonin syndrome following moclobemide–venlafaxine overdose
چکیده انگلیسی

To our knowledge, the majority of evidence supporting the relationship between the serotonin syndrome and medications that effect 5HT is based on case reports. The justification for taking up this subject has been a fatal outcome of a 21 year-old female following an administration of toxic doses of moclobemide (MAOI) and venlafaxine (SNRI). As a result of complex toxicological investigations including antemortem and postmortem material, antemortem clinical observations and postmortem examinations, the cause of death was identified as overdose with antidepressants – moclobemide and venlafaxine – in the mechanism of the clinically fully developed severe toxic serotonin syndrome.The analysis of a hair strand collected from the victim documented the use of the above-mentioned drugs simultaneously with cocaine in the period of at least 20 months preceding death. The fact is a matter of considerable interest in view of the employed pharmacotherapy, giving rise to suspicion that the woman had not developed the serotonin syndrome during the almost 2-year antemortem period until she took toxic doses of both medications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Forensic Science International - Volume 184, Issues 1–3, 30 January 2009, Pages e16–e20
نویسندگان
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