کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9743306 | 1491186 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fast determination of pKa values of reverse transcriptase inhibitor drugs for AIDS treatment by using pH-gradient flow-injection analysis and multivariate curve resolution
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Fast determination of pKa values of reverse transcriptase inhibitor drugs for AIDS treatment by using pH-gradient flow-injection analysis and multivariate curve resolution Fast determination of pKa values of reverse transcriptase inhibitor drugs for AIDS treatment by using pH-gradient flow-injection analysis and multivariate curve resolution](/preview/png/9743306.png)
چکیده انگلیسی
This paper aims at the characterization of acid-base properties of nucleoside analogs using a pH-gradient flow injection -diode array detector (FI-DAD) system and further data analysis with multivariate curve resolution. Drugs selected comprise nucleoside reverse transcriptase inhibitors (NRTIs) extensively used in AIDS treatment, including zidovudine (AZT), didanosine (ddl), stavudine (d4T) and zalcitabine (ddC). The FI system consists of a two-channel manifold in which the sample injection into an acid carrier is responsible of the generation of a pH gradient. A first step is focused on an accurate calibration of the pH-gradient shape inside the FI peak using nucleoside analogs of known pKa values as standard compounds. The pH gradient in the FI peak is estimated from the concentration profiles of standard compounds. In a second step, the pH-gradient profile is exploited for a rapid estimation of unknown pKa values of test drugs. Various approaches for calculating pKa values are evaluated using the peak front or peak tail gradient ranges. As a result, overall errors in pKa estimations are lower than 2.5%.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytica Chimica Acta - Volume 554, Issues 1â2, 4 December 2005, Pages 177-183
Journal: Analytica Chimica Acta - Volume 554, Issues 1â2, 4 December 2005, Pages 177-183
نویسندگان
Antonio Checa, VÃctor González Soto, Santiago Hernández-Cassou, Javier Saurina,