کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9743544 | 1491193 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The variance of screening and supersaturated design results as a measure for method robustness
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Screening designs are factorial designs to evaluate the importance of factors in a number of experiments that is at least one higher than the number of factors examined. Supersaturated designs are factorial designs with more factors than experiments. These designs do not allow a correct estimation of the factor effects due to a confounding of main effects. Therefore, it is evaluated whether, in robustness testing, the variance of a response can be used as a measure for the robustness of a method. A number of potential reference criteria (reference variances estimating reproducibility and limit values) also are evaluated for their applicability to decide whether the examined factors cause non-robustness. Finally, it was also examined which conclusions one statistically can draw from comparing the variances from the design experiments with the reference criteria. Two approaches are considered for the reference variances: a classical F-test and interval hypothesis testing. The use of some limit values was also discussed. It was found that the variance of a response could be used as a measure for robustness, but statistically this variance could not be interpreted in an acceptable way. Either a large probability to accept a non-robust or to reject a robust method occurs due to the small number of degrees of freedom to examine a given number of factors, especially when applying supersaturated designs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytica Chimica Acta - Volume 544, Issues 1â2, 15 July 2005, Pages 268-279
Journal: Analytica Chimica Acta - Volume 544, Issues 1â2, 15 July 2005, Pages 268-279
نویسندگان
B. Dejaegher, J. Smeyers-Verbeke, Y. Vander Heyden,