کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9743965 | 1491203 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Determination of chloramphenicol in honey by liquid chromatography-tandem mass spectrometry
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
An effective liquid chromatographic method with tandem mass spectrometric (LC-MS/MS) detection and identification is presented for the determination of chloramphenicol (CAP) in honey. After a preliminary dissolution in water, samples were extracted with a mixture of dichloromethane/acetone and evaporated to dryness; the following clean up was carried out on an octadecyl (C18) SPE cartridge. CAP was determined by LC-MS/MS, using electrospray ionization in the negative ion mode (ESIâ). The column was a LUNA Phenomenex with a mixture of methanol-aqueous ammonium acetate (60:40, v/v) as a mobile phase. Honey samples were fortified at CAP levels 0.30-0.45-0.60 μg kgâ1 with 5D-CAP as internal standard. At these levels, trueness ranged between 98.7 and 102.0% and within-laboratory reproducibility was lower than 6.2%, expressed as relative standard deviation. The limit of decision (CCα) was 0.07 μg kgâ1 and detection capability (CCβ) was 0.10 μg kgâ1.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytica Chimica Acta - Volume 529, Issues 1â2, 24 January 2005, Pages 257-263
Journal: Analytica Chimica Acta - Volume 529, Issues 1â2, 24 January 2005, Pages 257-263
نویسندگان
A.F. Forti, G. Campana, A. Simonella, M. Multari, G. Scortichini,