کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9745517 | 1491574 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Combinatorial libraries and the development of organic synthetic methods. PLS modelling to discriminate between successful and failed reaction systems
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Combinatorial libraries and the development of organic synthetic methods. PLS modelling to discriminate between successful and failed reaction systems Combinatorial libraries and the development of organic synthetic methods. PLS modelling to discriminate between successful and failed reaction systems](/preview/png/9745517.png)
چکیده انگلیسی
The paper describes a combinatorial study in which substrate structure, Lewis acid properties, and solvent properties were varied to explore the Fischer indole synthesis. The number of items in the combinatorial library was 254. Of these, 162 afforded the Fischer reaction. It is shown how PLS modelling can be used to identify critical properties of the reaction systems so that both conditions that are favourable for the reaction as well as conditions that fail can be identified. Transformation of the PLS models to response surface models makes it possible to analyse the properties of the reaction system in detail.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemometrics and Intelligent Laboratory Systems - Volume 78, Issues 1â2, 28 July 2005, Pages 113-124
Journal: Chemometrics and Intelligent Laboratory Systems - Volume 78, Issues 1â2, 28 July 2005, Pages 113-124
نویسندگان
Rolf Carlson, Hanna Gautun,