کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9748728 1493790 2005 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development and optimization of a stability indicating method on a monolithic reversed-phase column for Colchicum dry extract
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Development and optimization of a stability indicating method on a monolithic reversed-phase column for Colchicum dry extract
چکیده انگلیسی
This article presents a method developed on a monolithic reversed-phase column for separation of related alkaloids and degradation products from colchicine in dry extract preparations from Colchicum seeds. Optimization was performed using an optimization software with variation of the pH of the mobile phase and the percentage of organic modifier. This method permits for the first time a fast separation of all alkaloids including colchiceine without prior derivatization or complexation with excellent linearity, precision and low limits of quantitation which makes it a suitable method for stability testing of extracts or drug formulations containing extracts of Colchicum seeds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1089, Issues 1–2, 30 September 2005, Pages 148-157
نویسندگان
, ,