کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9748900 | 1493795 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of (+) or (â) camphorsulfonic acid additives to the mobile phase on enantioseparations of some basic drugs on a Chiralcel OD column
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effect of (+) or (â) camphorsulfonic acid additives to the mobile phase on enantioseparations of some basic drugs on a Chiralcel OD column Effect of (+) or (â) camphorsulfonic acid additives to the mobile phase on enantioseparations of some basic drugs on a Chiralcel OD column](/preview/png/9748900.png)
چکیده انگلیسی
This paper describes the modification of Chiralcel OD column properties by adsorption of (+) or (â) camphorsulfonic acids (CSAs) used as additives to the mobile phase. The effects on retention, selectivity and efficiency, of adsorption of (+) and (â) CSAs on a Chiralcel OD column were examined. Racemic anti-histamines, anti-malarial and anti-fungal drugs, namely doxylamine, miconazole, sulconazole, hydroxyzine, homochlorcyclizine, methoxypheniramine, cyclopentolate and ephedrine were investigated as chiral tested compounds. All the studied drugs have an amino nitrogen atom in their structure. Only the enantioseparation of ephedrine enantiomers with CSAs alone was studied on the Nucleosil stationary phase, and these results were compared with the results obtained on the Chiralcel OD phase. A new dynamically generated stationary phase, with very good enantioseparation ability towards the studied compounds, was obtained by the adsorption of (â) CSA on the Chiralcel OD column.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1083, Issues 1â2, 12 August 2005, Pages 133-140
Journal: Journal of Chromatography A - Volume 1083, Issues 1â2, 12 August 2005, Pages 133-140
نویسندگان
A. Bielejewska, K. Duszczyk, J. Żukowski,