کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9749061 | 1493800 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Separation of amino acids with simulated moving bed chromatography
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Authors have constructed an automatized four-column large laboratory scale (I.D. = 50 mm, L = 500 mm) simulated moving bed (SMB) equipment. The applied model system for separation of biomolecules is glycine, l-phenylalanine, water and Sepabeads SP825 adsorbent. The authors determined the adsorption equilibrium data and the packing characteristics. The operating conditions of SMB equipment were calculated with the help of the Morbidelli variables. During the SMB experiments, glycine and l-phenylalanine were separated in water on Sepabeads SP825 with an average particle size 0.3 mm at temperatures 20 °C and 60 °C. The measurement series were carried out on a four-column three-zone open loop SMB. Both l-phenylalanine and glycine were produced with more than 99.9% (m/m) purity and 99% yield at productivity 1.7-3.7, with productivity 3.7-8.1 mg/(g adsorbent h) in case of 2-1-1-0 column configuration. The measured and the calculated data agreed well.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1075, Issues 1â2, 20 May 2005, Pages 77-86
Journal: Journal of Chromatography A - Volume 1075, Issues 1â2, 20 May 2005, Pages 77-86
نویسندگان
Zoltán Molnár, Melinda Nagy, Antal Aranyi, László Hanák, János Argyelán, István Pencz, Tibor Szánya,