کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9749123 1493802 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
On the optimisation of the bed porosity and the particle shape of ordered chromatographic separation media
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
On the optimisation of the bed porosity and the particle shape of ordered chromatographic separation media
چکیده انگلیسی
We report on a theoretical study wherein we considered a large number of ordered two-dimensional porous pillar arrays with different pillar shapes and widely varying external porosity and calculated the flow resistance and the band broadening (under retentive conditions) over the complete range of practical velocities using a commercial computational fluid dynamics software package. It is found that the performance of the small porosity systems is very sensitive to the exact pillar shape, whereas this difference gradually disappears with increasing porosity. The obtained separation impedances are very small in comparison to packed bed and monolithic columns and decrease with increasing porosity. If accounting for the current micromachining limitations, a proper selection of the exact shape and porosity even becomes more critical, and different design rules are obtained depending on whether porous or non-porous pillars are considered.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1073, Issues 1–2, 6 May 2005, Pages 43-51
نویسندگان
, , , , , ,