کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9749247 | 1493805 | 2005 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structure elucidation of phase II metabolites by tandem mass spectrometry: an overview
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Structure elucidation of phase II metabolites by tandem mass spectrometry: an overview Structure elucidation of phase II metabolites by tandem mass spectrometry: an overview](/preview/png/9749247.png)
چکیده انگلیسی
The present paper provides a summary of the collision-induced dissociation of protonated and deprotonated phase II metabolites of drugs and pesticides. This overview is based on published literature and unpublished data from the authors. In particular, glutathione conjugates and their biotransformation products are discussed in detail. In addition, the fragmentation of the major classes of conjugates, i.e. glucuronides, glucosides, malonylglucosides, sulfates, acetates, methyl and glycine conjugates, is reported. Collision-induced dissociation, as studied by tandem mass spectrometry, allows the rapid identification of the type of conjugate, whereas the exact conjugation site can in general be determined only by additional NMR experiments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1067, Issues 1â2, 4 March 2005, Pages 55-72
Journal: Journal of Chromatography A - Volume 1067, Issues 1â2, 4 March 2005, Pages 55-72
نویسندگان
Karsten Levsen, Hans-Martin Schiebel, Beate Behnke, Reinhard Dötzer, Wolfgang Dreher, Manfred Elend, Herbert Thiele,