کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9749306 | 1493806 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Organic solvent high-field amplified stacking for basic compounds in capillary electrophoresis
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Organic solvent high-field amplified stacking for basic compounds in capillary electrophoresis Organic solvent high-field amplified stacking for basic compounds in capillary electrophoresis](/preview/png/9749306.png)
چکیده انگلیسی
Many water-miscible organic solvents, especially acetonitrile and acetone, bring along significant degrees (â¼30 times) of stacking by electroinjection through high-field amplified injection for the basic compounds compared to that for aqueous buffers or water. The relative stacking of different compounds in acetonitrile or acetone is different compared to that for water. Stacking by electroinjection in organic solvents is less stringent and easier to accomplish in practice. Acids and salts, in aqueous solutions, can ruin the stacking for both organic and aqueous solvents; however, this effect can be better tolerated by diluting the sample in acetonitrile. Thus, this stacking is termed “organic solvent high-field amplified injection”. This stacking by electroinjection is enhanced by increasing the electrophoresis buffer concentration and can be better than that by pressure injection. From the practical aspects, some cationic drugs present in serum such as amiodarone can be detected at the therapeutic levels by electroinjection on the capillary after protein precipitation by acetonitrile.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1066, Issues 1â2, 25 February 2005, Pages 205-210
Journal: Journal of Chromatography A - Volume 1066, Issues 1â2, 25 February 2005, Pages 205-210
نویسندگان
Zak K. Shihabi,