کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9754493 | 1494679 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Application of GC-EI-MS for the identification and investigation of positional isomer in primaquine, an antimalarial drug
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A major impurity associated with primaquine drug samples obtained from European Pharmacopoeia (EP) and other commercial sources was detected and identified using HPLC, photo diode array (PDA), LC-MS/MS and gas chromatograph-electron impact-mass spectrometer (GC-EI-MS). PDA and LC-ESI-MS/MS data provided an evidence for it being isomeric in nature. However, spectral data obtained from the newly developed GC-EI-MS method has been utilised for structural elucidation and found to be conclusive to characterize this impurity as positional isomer, i.e. 8-(4-amino-4-methylbutyl amino)-6 methoxyquinoline. The structure of this impurity has been confirmed by its synthesis. Precursor of primaquine was also investigated using GC-EI-MS. The data obtained confirmed the origin of isomeric impurity in precursor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 39, Issues 1â2, 1 September 2005, Pages 111-116
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 39, Issues 1â2, 1 September 2005, Pages 111-116
نویسندگان
Vaijanath G. Dongre, Pravin P. Karmuse, M.M. Nimbalkar, Dharmendra Singh, Ashok Kumar,