کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9757465 | 1496004 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Choices for tissue visualization with IR microspectroscopy
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this paper, we address some of the issues associated with infrared (IR) imaging, with reference to our work on brain tissue from the TgCRND8 mouse, a transgenic model of Alzheimer's disease (AD). AD is the most common cause of dementia in the aging population. One of the characteristic hallmarks of this chronic neurodegenerative disorder is the accumulation of plaques in the brain, usually visualized with histochemistry and immunostaining. Although these methods are extremely useful, they illustrate only certain aspects of the sample, require a great amount of tissue processing, and are highly dependent on experimental protocols and reagent quality. IR imaging provides information on multiple components, with a minimal amount of sample processing. However, in order to interpret the data successfully, the issues of spectral acquisition parameters, pre-processing, and spectral artifacts need to be considered. The methods commonly used to process the data, such as uni- and bi-variate spectral analysis, and multivariate methods, such as hierarchical cluster analysis, and some issues concerning the use of second derivatives of IR spectra are discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vibrational Spectroscopy - Volume 38, Issues 1â2, 29 July 2005, Pages 133-141
Journal: Vibrational Spectroscopy - Volume 38, Issues 1â2, 29 July 2005, Pages 133-141
نویسندگان
Kathleen Gough, Margaret Rak, Adam Bookatz, Marc Del Bigio, Sabine Mai, David Westaway,