کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9757619 | 1496378 | 2005 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential effects of oleuropein, a biophenol from Olea europaea, on anionic and zwiterionic phospholipid model membranes
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
DSC16-NS5-NS1,2-Dimyristoyl-sn-glycero-3-phosphategel to liquid-crystalline phase transition temperature1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamineSteady-state fluorescence anisotropyMLVs1,2-dielaidoyl-sn-glycero-3-phosphoethanolamineDEPEDMPEDPPGViral haemorrhagic septicaemia virusLUVsDMPGDMPSDPHVHSVDMPAOLEdMPC1,2-dimyristoyl-sn-glycero-3-phosphocholine - 1،2-dimyristoyl-sn-glycero-3-phosphosocholine1,6-diphenyl-1,3,5-hexatriene - 1،6-دیفنیل-1،3،5-هگزیدریلmultilamellar vesicles - vesicles multilamellar16-doxyl-stearic acid - اسید 16-دکسیل استاریک5-doxyl-stearic acid - اسید 5-دکسیل استاریکphosphatidic acid - اسید فسفاتیدیکOleuropein - اولوروپینHII - اینlarge unilamellar vesicles - بزرگ کیسه های بدون انعطاف پذیرonset temperature of the gel to liquid-crystalline phase transition - شروع دمای ژل به انتقال فاز مایع بلورینPhospholipid membranes - غشای فسفولیپیدphosphatidylcholine - فسفاتیدیل کولینphosphatidylglycerol - فسفاتیدیل گلیسرولphosphatidylethanolamine - فسفاتیدیلتانولامینPhosphatidylserine - فسفاتیدیلسرینFluorescence - فلورسنسAntimicrobial - ماده ضد میکروبی یا آنتی میکروبیالDifferential scanning calorimetry - کالریمتری روبشی افتراقیhigh performance liquid chromatography - کروماتوگرافی مایع با کارایی بالاHPLC - کروماتوگرافی مایعی کارا
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Differential effects of oleuropein, a biophenol from Olea europaea, on anionic and zwiterionic phospholipid model membranes Differential effects of oleuropein, a biophenol from Olea europaea, on anionic and zwiterionic phospholipid model membranes](/preview/png/9757619.png)
چکیده انگلیسی
Oleuropein (Ole) is the major phenolic constituent of the olive leaf (Olea europaea) and it is also present in olive oil and fruit. In the last years several compounds from olive tree, oleuropein among them, have shown a variety of biological activities such as antimicrobial or antioxidant. A phospholipid model membrane system was used to study whether the Ole biological effects could be membrane related. Ole showed a significant partition level in phospholipid membranes, i.e. 80%, at lipid-saturating conditions. Moreover, fluorescence quenching experiments indicated a shallow location for Ole in membranes. Ole promoted weak effects on zwiterionic phospholipids such as phosphatidylcholine or phosphatidylethanolamine. In contrast, differential scanning microcalorimetry, light scattering and fluorescence anisotropy pH titration studies revealed strong effects on anionic phospholipids such as phosphatidylglycerol at physiological pH and salt conditions. These effects consisted on perturbations at the phospholipid membrane surface, which might involve specific molecular interactions between Ole and the negatively charged phosphate group and therefore modify the phospholipid/water interface properties. It is proposed that Ole induces lipid structures similar to the gel-fluid intermediate phase (IP) described for PG membranes, in a similar way than low ionic strength does. These effects on phosphatidylglycerol may account for the antimicrobial activity of Ole.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemistry and Physics of Lipids - Volume 137, Issues 1â2, October 2005, Pages 2-17
Journal: Chemistry and Physics of Lipids - Volume 137, Issues 1â2, October 2005, Pages 2-17
نویسندگان
Nuria Caturla, Laura Pérez-Fons, Amparo Estepa, Vicente Micol,