کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
976 70 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hydrophobic nanopillars initiate mesenchymal stem cell aggregation and osteo-differentiation
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Hydrophobic nanopillars initiate mesenchymal stem cell aggregation and osteo-differentiation
چکیده انگلیسی

Surface engineering approaches that alter the physical topography of a substrate could be used as an effective tool and as an alternative to biochemical means of directing stem cell interactions and their subsequent differentiation. In this paper we compare hydrophobic micro- vs. nanopillar type fabrication techniques for probing mesenchymal stem cell (MSC) interaction with the surface physical environment. The roles played by the topography of the nanopillar in particular influenced MSC growth and allowed for regulatory control of the stem cell fate. The nanopillar induced large 3-D cell aggregates to form on the surface which had up-regulated osteogenic specific matrix components. The ability to control MSC differentiation, using only the topographical factors, has a profound effect on both MSC biology and tissue engineering. This study aims to highlight the importance of the physical material carrier in stem cell based tissue engineering schemes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Biomaterialia - Volume 7, Issue 2, February 2011, Pages 683–690
نویسندگان
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