کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9770329 | 1501945 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design of peptides with α, β-dehydro-residues: synthesis and crystal structure of a tripeptide N-benzyloxycarbonyl-ÎVal-ÎPhe-l-Ala-OCH3
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Design of peptides with α, β-dehydro-residues: synthesis and crystal structure of a tripeptide N-benzyloxycarbonyl-ÎVal-ÎPhe-l-Ala-OCH3 Design of peptides with α, β-dehydro-residues: synthesis and crystal structure of a tripeptide N-benzyloxycarbonyl-ÎVal-ÎPhe-l-Ala-OCH3](/preview/png/9770329.png)
چکیده انگلیسی
In order to develop the design rules for producing specific conformations of peptides with α, β-dehydro-residues a peptide Cbz-ÎVal-ÎPhe-Ala-OCH3 was synthesized in solution phase. The crystal structure has been determined by X-ray diffraction method. The structure was refined to an R-value of 0.050. The peptide adopts a type I β-turn conformation with backbone torsion angles of two corner residues, Ï1=â53.9(6)°, Ï1=â33.0(6)°, Ï2=â73.7(5)° and Ï2=â12.2(6)°. The conformation is stabilized by an intramolecular 4â1 hydrogen bond involving NH of Ala residue as a donor and carbonyl oxygen atom of Cbz group as an acceptor. The torsion angles, Ï11,1=172.8(6) and Ï11,2=â6.9(9) of ÎVal residue indicate that its side chain is planar while the torsion angles, Ï21=â9.0(9), Ï22,1=â43.4(10) and Ï22,2=130.1(9) show that the side chain of ÎPhe deviates considerably from the planarity. This is the first sequence in which ÎVal and ÎPhe are introduced at adjacent positions and the structure reveals clearly that the side chain of ÎPhe is a relatively less rigid than that of ÎVal. The molecules are packed in columns parallel to c-axis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 738, Issues 1â3, 14 March 2005, Pages 189-192
Journal: Journal of Molecular Structure - Volume 738, Issues 1â3, 14 March 2005, Pages 189-192
نویسندگان
Vijay Kumar Goel, Sharmistha Dey, Tej P. Singh,