کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9770351 | 1501946 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design rules for peptides with α, β-dehydro-residues: synthesis of a model peptide Boc-Ile-ÎAla-OCH3 and its crystal structures obtained from two different solvents
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
The peptide Boc-Ile-ÎAla-OCH3 was synthesized and its three dimensional structure was determined using crystals grown under two different conditions using solvents (a) ethyl acetate and (b) an 80:20 mixture of dichloromethane and heptane. In the first case, the peptide crystallized in space group P21 with six crystallographically independent molecules while in the second condition the peptide crystallized in space group P32 with four molecules in the asymmetric unit. In both structures the conformations of all the crystallographically independent molecules were almost identical. ÎAla adopted a planar conformation with the Ï torsion angle having values centred at ±180° in all the molecules. The crystal structures in two different crystalline states showed that ÎAla induced a distorted inverse γ-turn in the preceding residue with Ï and Ï torsions centred at 100(1) and â125(1)°, respectively. The molecular packing in both crystal forms generated the sheet-like structures that were stabilized by intermolecular hydrogen bonds between the layers of molecules.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 737, Issues 2â3, 4 March 2005, Pages 109-116
Journal: Journal of Molecular Structure - Volume 737, Issues 2â3, 4 March 2005, Pages 109-116
نویسندگان
S. Dey, R. Vijayaraghavan, V.K. Goel, S. Kumar, P. Kumar, T.P. Singh,