کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9774582 | 1509089 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparison of novel delivery systems for antisense peptide nucleic acids
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Comparison of novel delivery systems for antisense peptide nucleic acids Comparison of novel delivery systems for antisense peptide nucleic acids](/preview/png/9774582.png)
چکیده انگلیسی
We here compare the efficacy of three different delivery strategies for antisense PNA: 1) conjugation to hydrophobic peptides, 2) adsorption onto polymeric microspheres and 3) encapsulation in autologous erythrocytes. To this purpose, we designed and prepared PNA sequences able to inhibit the expression of macrophage enzymes involved in inflammatory process, i.e. nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) and tested their antisense activity in a murine macrophage cellular model. Both delivery through polymeric microspheres and encapsulation into erythrocytes allowed the antisense activity of unmodified PNAs at nanomolar concentration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 109, Issues 1â3, 5 December 2005, Pages 24-36
Journal: Journal of Controlled Release - Volume 109, Issues 1â3, 5 December 2005, Pages 24-36
نویسندگان
Laura Chiarantini, Aurora Cerasi, Alessandra Fraternale, Enrico Millo, Umberto Benatti, Katia Sparnacci, Michele Laus, Marco Ballestri, Luisa Tondelli,