کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9774662 | 1509091 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oligonucleotide-protamine-albumin nanoparticles: Protamine sulfate causes drastic size reduction
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Nanoparticles prepared by self-assembly from oligonucleotides (ONs), protamine free base, and human serum albumin (“ternary proticles”) are spheres of diameters around 200 nm. Substitution of the protamine free base by protamine sulfate leads to proticles of only around 40 nm in diameter with otherwise unchanged properties. The availability of drug delivery systems of very similar composition but grossly different size may be advantageous when dealing with cells which show size-dependent particle uptake. These nanoparticles are promising candidates for ON delivery to cells because of the following reasons: (1) They are stable for several hours in solutions of up to physiological ionic strength; (2) they are efficiently taken up by cells; (3) after cellular uptake, they easily release the ONs even when these are present as phosphorothioates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 106, Issues 1â2, 18 August 2005, Pages 181-187
Journal: Journal of Controlled Release - Volume 106, Issues 1â2, 18 August 2005, Pages 181-187
نویسندگان
Gottfried Mayer, Vitali Vogel, Jörg Weyermann, Dirk Lochmann, Jacomina A. van den Broek, Christos Tziatzios, Winfried Haase, Daan Wouters, Ulrich S. Schubert, Andreas Zimmer, Jörg Kreuter, Dieter Schubert,