کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9801097 | 1515174 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Histomorphometric analysis of glucocorticoid-induced osteoporosis
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کلمات کلیدی
BFR/BSactivation frequencytrabecular bone pattern factorTbPfbone formation rate/bone surfaceTb.NTb.SpTb.ThMARBV/TV - BV / TVICI - اینجاBisphosphonates - بیس فسفوناتFractal analysis - تجزیه و تحلیل فراکتالtrabecular separation - جداسازی ترابکولارBone volume - حجم استخوانtrabecular number - شماره تراککالtrabecular thickness - ضخامت تراککالWall thickness - ضخامت دیوارMineral apposition rate - میزان جذب مواد معدنیMicroarchitecture - میکارشیکتوریHistomorphometry - هیستومورفومتریOsteoporosis - پوکی استخوانGlucocorticoids - گلوکوکورتیکوئیدها
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
دانش مواد (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Concerning the bone formation, some histomorphometric studies have shown a depressed osteoblastic activity at a cell, bone remodeling unit, and tissue levels. In addition, there is evidence of a shortening of the period in which the osteoblasts work actively forming the bone matrix. This latter effect seems to occur after high cumulative doses of GC. With regard to the resorption, the results are still debated, but histomorphometric parameters seem to be increased in the majority of studies, at least in the first period of the GC treatment. From a structural point of view, GC seem to induce a thinning of the trabeculae without their perforation, which occurs only after high cumulative doses. Antiresorptive treatments, such as bisphosphonates, are able to counteract the negative effects of GC on bone. In particular, along with their active working period, they prolong the lifespan of osteoblasts and osteocytes. In addition, the antiresorptive treatments seem to extend the time for secondary mineralization through a reduction of the Activation Frequency. The latter is an intriguing mechanism of bisphosphonates in GIO that needs further ad hoc investigations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Micron - Volume 36, Issues 7â8, OctoberâDecember 2005, Pages 645-652
Journal: Micron - Volume 36, Issues 7â8, OctoberâDecember 2005, Pages 645-652
نویسندگان
L. Dalle Carbonare, F. Bertoldo, M.T. Valenti, S. Zenari, M. Zanatta, S. Sella, S. Giannini, V. Lo Cascio,