کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9881271 1535694 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Membrane alteration as a basis of aging and the protective effects of calorie restriction
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Membrane alteration as a basis of aging and the protective effects of calorie restriction
چکیده انگلیسی
As has been experimentally determined, oxidative modification to biological systems can be extensive, although the identification and stochiometric relation of the reactive species that cause these alterations have not been fully elucidated. In this review, arguments are presented to support the notion that the combined effects of membrane lipid peroxidation and its by-products, reactive aldehydes are likely responsible for membrane-associated functional declines during aging. As evidence for a systemic response to overall oxidative stress, the molecular inflammation hypothesis of aging is discussed by considering that the activation of inflammatory genes act as a bridge linking normal aging to pathological processes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 126, Issue 9, September 2005, Pages 1003-1010
نویسندگان
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