کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9881367 | 1535700 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biological evidence for inheritance of exceptional longevity
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کلمات کلیدی
High-density lipoprotein (HDL) cholesterolLow-density lipoprotein (LDL) cholesterolLongevity - دیرزیستی یا طول عمرLipoprotein particle size - اندازه ذرات لیپوپروتئینcardiovascular disease - بیماری قلب و عروقیcentenarians - صد سالگیCognitive function - عملکرد شناختیCholesteryl ester transfer protein (CETP) - پروتئین انتقال کلسترول استر (CETP)Genetics - ژنتیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We demonstrated that exceptional longevity and healthy aging in humans is an inherited phenotype across three generations. Moreover, we demonstrated that subjects with exceptional longevity and their offspring have significantly larger high-density lipoprotein (HDL) levels and particle sizes and low-density lipoprotein (LDL) levels that reflect on their health and cognitive function performance. This phenotype have led us to study candidate genes involved in lipoprotein metabolism, and to the implication of homozygosity for the 405 valine (V) allele of cholesteryl ester transfer protein (CETP). A markedly higher frequency of a functional CETP variant that led to increased particle sizes of HDL and LDL and thus a better health performance is the first example of a phenotype and an associated genotype in humans with exceptional longevity. Hopefully, this line of research will lead us to establish which genotype is necessary (although not necessary sufficient) for a prolonged disease-free aging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 126, Issue 2, February 2005, Pages 341-345
Journal: Mechanisms of Ageing and Development - Volume 126, Issue 2, February 2005, Pages 341-345
نویسندگان
Gil Atzmon, Marielisa Rincon, Pegah Rabizadeh, Nir Barzilai,