کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9881377 | 1535701 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Large-scale identification in yeast of conserved ageing genes
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
Recent advances have suggested the existence of phylogenetically conserved pathways regulating ageing in eukaryotes. At least two of these “public” longevity-determining pathways appear to have been evolutionarily conserved from yeast through mammals. We have developed a high-throughput, genome-wide approach to identify a large fraction of the non-essential, single-gene deletion mutations that confer increased longevity in yeast. The identification and characterization of conserved genes that regulate the ageing process across eukaryotic species is likely to result in an improved understanding of the causes of human ageing and provide potential therapeutic targets for drug discovery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 126, Issue 1, January 2005, Pages 17-21
Journal: Mechanisms of Ageing and Development - Volume 126, Issue 1, January 2005, Pages 17-21
نویسندگان
Matt Kaeberlein, Brian K. Kennedy,