کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9881390 1535701 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A genetic and genomic approach to identify longevity genes in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
A genetic and genomic approach to identify longevity genes in mice
چکیده انگلیسی
Natural variation in rate of aging or longevity in mice and humans shows a very complex inheritance pattern. Few targeted genetic screens have identified longevity genes in mammals, partly as a result from the fact that the genetics of longevity can only be studied reliably in cohorts of mice. In this paper we propose that a combined genetic and genomic analysis of large families of fully genotyped recombinant inbred mice may provide a crucial tool to the aging research community. As a proof of principle we describe preliminary studies in which variation in gene expression patterns in hematopoietic stem cells and brain were genetically linked to longevity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 126, Issue 1, January 2005, Pages 133-138
نویسندگان
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