کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9884439 1536794 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Allele effects in MHC-peptide interactions: A theoretical analysis of HLA-DRβ1*0101-HA and HLA-DRβ1*0401-HA complexes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Allele effects in MHC-peptide interactions: A theoretical analysis of HLA-DRβ1*0101-HA and HLA-DRβ1*0401-HA complexes
چکیده انگلیسی
HLA-DRβ1*0101-HA and HLA-DRβ1*0401-HA complexes are studied and compared by means of their computationally derived multipolar moments and electrostatic potentials. Changes in electrostatic potential are associated with definite pocket interaction profiles. Thus, Pocket 1 projects itself as an anchoring pocket for both complexes, in accordance with experimental results. While Pocket 4 has an anchoring profile in the HLA-DRβ1*0101 allele, it presents itself as modulating pocket-peptide interactions in HLA-DRβ1*0401. Pockets 6 and 7 both strongly contribute to allele specificity, with Pocket 7 being very important for HLA-DRβ1*0401-HA. Pocket 9 acts as a “double purpose” interaction site for both alleles. It both projects itself as an anchoring pocket as well as modulating pocket-peptide interactions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 330, Issue 4, 20 May 2005, Pages 1162-1167
نویسندگان
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