کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9885512 1537326 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transcriptional regulation of human CC chemokine CCL15 gene by NF-κB and AP-1 elements in PMA-stimulated U937 monocytoid cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Transcriptional regulation of human CC chemokine CCL15 gene by NF-κB and AP-1 elements in PMA-stimulated U937 monocytoid cells
چکیده انگلیسی
CCL15 exerts biological effects on a variety of cells, including monocytes. NF-κB has been reported to be involved in the transcription of the CCL15 gene. In this study, we have identified an AP-1 element located at −76/−65, which appears to regulate the transcription of the CCL15 gene. We also confirmed that the AP-1 factor binds to the element. Specific inhibitors for MAPK pathways and expression of dominant negative MKK4 or JNK1 reduced PMA-induced transcriptional activation of CCL15. Our findings indicate that transcription of the CCL15 gene is regulated by AP-1 and NF-κB through MEK and JNK MAPK pathways in monocytoid cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression - Volume 1732, Issues 1–3, 30 December 2005, Pages 38-42
نویسندگان
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