کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9887787 | 1538439 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of metazoan replication-dependent histone genes
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کلمات کلیدی
ORFeukaryotic initiation factor 4GStem-Loop Binding ProteinPABPeIF3SLBPHDEeIF4GHBPeIF4ENPCRBD3′ UTR - 3 UTR3′ untranslated region - 3 منطقه غیر ترجمهCho - برایChinese Hamster Ovary - تخمدان هامستر چینیbase pair - جفت پایهRNA-binding domain - دامنه اتصال RNAribonucleotides - ریبونوکلئوتیدTAP - ضربه زدنEukaryotic initiation factor 3 - عامل شروع یوکاریوتی 3open reading frame - قاب خواندن بازnuclear pore complex - مجتمع مخرب هسته ای
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Histone proteins are essential components of eukaryotic chromosomes. In metazoans, they are produced from the so-called replication-dependent histone genes. The biogenesis of histones is tightly coupled to DNA replication in a stoichiometric manner because an excess of histones is highly toxic for the cell. Therefore, a strict cell cycle-regulation of critical factors required for histone expression ensures exclusive S-phase expression. This review focuses on the molecular mechanisms responsible for such a fine expression regulation. Among these, a large part will be dedicated to post-transcriptional events occurring on histone mRNA, like histone mRNA 3â² end processing, nucleo-cytoplasmic mRNA export, translation and mRNA degradation. Many factors are involved, including an RNA-binding protein called HBP, also called SLBP (for hairpin- or stem-loop-binding protein) that binds to a conserved hairpin located in the 3â² UTR part of histone mRNA. HBP plays a pivotal role in the expression of histone genes since it is necessary for most of the steps of histone mRNA metabolism in the cell. Moreover, the strict S-phase expression pattern of histones is achieved through a fine cell cycle-regulation of HBP. A large part of the discussion will be centered on the critical role of HBP in histone biogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 87, Issues 9â10, SeptemberâOctober 2005, Pages 827-834
Journal: Biochimie - Volume 87, Issues 9â10, SeptemberâOctober 2005, Pages 827-834
نویسندگان
Sophie Jaeger, Sharief Barends, Richard Giegé, Gilbert Eriani, Franck Martin,