Keywords: mTOR; MNK; eIF4E; eIF4A; AMPK; Nociceptor; Sensitization;
مقالات ISI (ترجمه نشده)
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Keywords: Irradiation; Caspase 3; Angiogenesis; COX-2/PGE2; VEGF-A; COX-2; cyclooxygenase-2; PGE2; prostaglandin E2; eIF4E; eukaryotic initiation factor 4E; VEGF-A; vascular endothelial growth factor-A; GBM; glioblastoma;
Keywords: oxygen; hypoxia; cancer; translation; RNA sequencing; SILAC; eIF4E; eIF4E2; eIF4F; HIF
Keywords: bone marrow mesenchymal stem cells (BM-MSCs); Multiple myeloma; Translation initiation; eIF4E; eIF4GI; Microvesicles;
Keywords: CIR; carbon ion radiation; 2-DE; two-dimensional gel electrophoresis; MALDI-TOF-TOF; matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry; HIRFL; Heavy Ion Research Facility in Lanzhou; CCB; Colloidal Coomassie Blue G 250; T
Keywords: OS; overall survival; MAPK; mitogen-activated protein kinase; RTKs; receptor tyrosine kinases; PI3K; phosphatidylinositide 3-kinases; GEFs; guanine nucleotide exchange factors; GAPs; GTPase-activating proteins; FTIs; farnesyltransferase inhibitors; mTOR;
Keywords: hAECs; human aortic endothelial cells; oxLDL; oxidized low-density lipoprotein; nLDL; native low-density lipoprotein; GPX; glutathione peroxidase; IGF-1; insulin-like growth factor 1; Apoe; apolipoprotein e; ROS; reactive oxygen species; l-NAME; NG-nitro-
Keywords: FOXO; forkhead box O; GC; glucocorticoids; MuRF-1; muscle RING-finger protein-1; mTOR; mammalian target of rapamycin; IGF-I; Insulin-like Growth Factor-I; eIF4E; eukaryotic translation initiation factor 4E; S6K1; ribosomal protein kinase 1; 4E-BP1; eukary
Keywords: BDNF; brain derived neurotrophic factor; CAMKII; calmodulin-dependent protein kinase II; Ca2+; calcium; cAMP; cyclic adenosine monophosphate; CBS; cystathionine-β-synthase; CCI; chronic constriction injury; CFA; complete Freund's adjuvant; cGMP; cyclic
Inhibition of eukaryotic translation initiation factor 4E is effective against chemo-resistance in colon and cervical cancer
Keywords: eIF4E; Ribavirin; VEGF; c-Myc; Chemoresistance; Cancer therapy;
Strategies of biochemical adaptation for hibernation in a South American marsupial, Dromiciops gliroides: 2. Control of the Akt pathway and protein translation machinery
Keywords: 4EBP; eukaryotic translation initiation factor 4E-binding protein; Akt; protein kinase B; eIF2α; eukaryotic translation initiation factor 2A; eIF4e; eukaryotic translation initiation factor 4E; GSK-3α; glycogen synthase kinase 3 alpha; GSK-3β; glycogen
Tracking the m7G-cap during translation initiation by crosslinking methods
Keywords: U; units; Cap-dependent translation; UV crosslinking; Chemical crosslinking; Ribosome; Histone H4 mRNA; eIF4E;
Preparation of polysomal fractions from mouse brain synaptoneurosomes and analysis of polysomal-bound mRNAs
Keywords: Synaptoneurosomes; Polyribosome fractionation; RNA; Protein; Mmp9; matrix metalloproteinase 9; Camk2a; calcium/calmodulin-dependent protein kinase II alpha; Stx1B; syntaxin1B; Bdnf; brain-derived neurotrophic factor; TrkB; tyrosine receptor kinase B; eIF4
eIF4E Phosphorylation in Prostate Cancer
Keywords: eIF4E; eukaryotic translation initiation factor 4E; mTOR; mammalian target of rapamycin; PCa; prostate cancer; Mnk; mitogen activated protein kinase interacting protein kinase; ADT; androgen deprivation therapy; MAPK; mitogen-activated protein kinase; CRP
PI3K pathway in prostate cancer: All resistant roads lead to PI3K
Keywords: CRPC; castration-resistant prostate cancer; ADT; androgen deprivation therapy; PI3K; phosphoinositide 3-kinase; AR; androgen receptor; PTEN; phosphatase and tensin homologue deleted on chromosome 10; INPP4B; inositol polyphosphate 4-phosphatase type II; P
Overexpression of eIF4F components in meningiomas and suppression of meningioma cell growth by inhibiting translation initiation
Keywords: Protein translation; eIF4F; eIF4A; eIF4E; eIF4G; Meningioma; Neurofibromatosis type 2 (NF2); Merlin; Silvestrol;
Early dietary restriction in rats alters skeletal muscle tuberous sclerosis complex, ribosomal s6 and mitogen-activated protein kinase
Keywords: Muscle, skeletal; Rats; Diet reducing; Fetal growth retardation; TOR serine-threonine kinase; Mitogen-activated protein kinase phosphatases; 4EBP1; 4E binding protein-1; AMP; adenosine monophosphate-activated protein; CON; control; eIF4E; eukaryotic tra
Novel combined Ato-C treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells in vitro and in vivo
Keywords: Arsenic trioxide; Cisplatin; Combination therapy; Bcr-Abl-positive leukemia; Apoptosis; APL; acute promyelocytic leukemia; ATO; arsenic trioxide; Ato-C; ATO/CDDP; CDDP; Cisplatin; CI; combination index; DRI; dose-reduction index; CML; Chronic myelogenous
Autophagy as a pharmacological target in hematopoiesis and hematological disorders
Keywords: 3-MA; 3-methyladenine; ALL; acute lymphoblastic leukemia; AMKL; acute megakaryoblastic leukemia; AML; acute myeloid leukemia; AMPK; 5â²-adenosine monophosphate-activated protein kinase; APL; acute promyelocytic leukemia; Atg; autophagy-related proteins;
Dual targeting of eIF4E by blocking MNK and mTOR pathways in leukemia
Keywords: Translation initiation; eIF4E; MNK; mTOR; Acute myeloid leukemia;
Arginine methyltransferase inhibitor 1 inhibits gastric cancer by downregulating eIF4E and targeting PRMT5
Keywords: Gastric cancer; Arginine methyltransferase inhibitor 1 (AMI-1); Protein arginine methyltransferase 5 (PRMT5); Histonemethylation; eIF4E;
BAY 1143269, a novel MNK1 inhibitor, targets oncogenic protein expression and shows potent anti-tumor activity
Keywords: MAP kinase-interacting kinase 1; Non-small cell lung cancer; eIF4E; Small molecule kinase inhibitor; Anti-cancer therapy; AML; acute myeloid leukemia; ATP; adenosine triphosphate; BID; twice daily; CDK; cyclin-dependent kinase; DMSO; dimethyl sulfoxide; e
Phosphorylation of Tudor-SN, a novel substrate of JNK, is involved in the efficient recruitment of Tudor-SN into stress granules
Keywords: SG; stress granule; Tudor-SN; Tudor staphylococcal nuclease; JNK; c-Jun N-terminal kinase; PKR; protein kinase R; PERK; PKR-like endoplasmic reticulum kinase; GCN2; general control nonderepressible 2; HRI; heme-regulated inhibitor kinase; eIF2α; eukaryot
Structural analysis of ribosomal RACK1 and its role in translational control
Keywords: RACK1; Receptor for activated C-Kinase 1; rRNA; Ribosomal RNA; mRNA; Messenger RNA; PKC; Protein kinase C; eIF6; Eukaryotic initiation factor 6; eIF3; Eukaryotic initiation factor 3; eIF4E; Eukaryotic initiation factor 4E; Src; Sarcoma family kinase; Scp1
Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1α via the mTOR/p70S6K/4E-BP1 and MAPK pathways
Keywords: HIF-1; hypoxia-inducible factor-1; PI3K; phosphatidylinositol 3-kinase; mTOR; mammalian target of rapamycin; MAPK; mitogen-activated protein kinase; VEGF; vascular endothelial growth factor; EPO; erythropoietin; Topo-I; topoisomerase-I; eIF4E; eukaryotic
ReviewReappraisal to the study of 4E-BP1 as an mTOR substrate - A normative critique
Keywords: mTOR; 4E-BP; eIF4E; Rapamycin; Post-translational modification;
Antiviral Drug Ribavirin Targets Thyroid Cancer Cells by Inhibiting the eIF4E-β-Catenin Axis
Keywords: Ribavirin; eIF4E; β-catenin; Thyroid cancer; Drug repurposing;
The estrogen metabolite 2-methoxyestradiol regulates eukaryotic initiation factor 4E (eIF4E) and inhibits protein synthesis in MG63 osteosarcoma cells
Keywords: 2-Methoxyestradiol; 4E-BP; Estrogen metabolite; eIF4E; Osteosarcoma
Inhibition of eukaryotic initiation factor 4E phosphorylation by cercosporamide selectively suppresses angiogenesis, growth and survival of human hepatocellular carcinoma
Keywords: Cercosporamide; MNK; eIF4E; Angiogenesis; Hepatocellular carcinoma;
Antibiotic drug rifabutin is effective against lung cancer cells by targeting the eIF4E-β-catenin axis
Keywords: Rifabutin; eIF4E; β-catenin; Lung cancer; Drug repositioning;
The MNK-1/eIF4E pathway as a new therapeutic pathway to target inflammation and remodelling in asthma
Keywords: ASMC; Asthma; MNK-1; eIF4E; CGP57380;
Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation
Keywords: Cancer; eIF4E; Protein synthesis; mRNA translation; Cap-binding inhibitor; eIF; eukaryotic translation initiation factor; 4E-BP; eF4E-binding protein; FP; fluorescence polarisation; m7G; N7-methyl guanosine; RRL; rabbit reticulocyte lysate;
Oncogenic KRAS signaling and YAP1/β-catenin: Similar cell cycle control in tumor initiation
Keywords: YAP1; Yes; MAPK; mitogen-activated protein kinase; ERK; extracellular signal-regulated kinase; eIF4E; eukaryotic translation initiation factor 4E; PI3K; phosphatidylinositide-3-kinase; WNT; Wingless-type mouse mammary tumor virus integration site family m
Polymerase delta-interacting protein 2 regulates collagen accumulation via activation of the Akt/mTOR pathway in vascular smooth muscle cells
Keywords: Akt; protein kinase B; Atg; autophagy-related gene; ECM; extracellular matrix; 4E-BP1; eukaryotic initiation factor 4E binding protein 1; eIF4E; eukaryotic translation initiation factor 4E; Hsc70; heat shock cognate protein 70; LC3B; microtubule-associate
Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy
Keywords: MNK; MAP kinase-interacting kinase; TMZ; temozolomide; GBM; glioblastoma; MTC; medullary thyroid carcinoma; ERK; extracellular signal-regulated kinases; eIF4E/G1; eukaryotic translation initiation factor 4E/G1; MAPK; mitogen-activated protein kinase; GAPD
Effect of different N7 substitution of dinucleotide cap analogs on the hydrolytic susceptibility towards scavenger decapping enzymes (DcpS)
Keywords: mRNA degradation; Cap analogs; Enzyme kinetic; Decapping scavengers; Fluorescence titration; A. suum.; Ascaris suum; C. elegans; Caenorhabditis elegans; CBC; cap-binding complex; DcpS; decapping scavenger; DTT; dithiotreitol; eIF4E; eukaryotic initiatio
Five eIF4E isoforms from Arabidopsis thaliana are characterized by distinct features of cap analogs binding
Keywords: eIF4E; Cap analog; Binding affinity; Fluorescence titration; Homology modeling;
Parthenolide induces autophagy via the depletion of 4E-BP1
Keywords: PTL; parthenolide; eIF4E; eukaryotic initiation factor 4E; 4E-BP1; translation initiation factor eIF4E binding protein 1; AML; acute myeloid leukemia; ER; endoplasmic reticulum; ROS; reactive oxygen species; mTOR; mammalian target of rapamycin; MEF; mouse
Rapamycin-induced G1 cell cycle arrest employs both TGF-β and Rb pathways
Keywords: mTOR; Rapamycin; Rb; TGF-β; eIF4E; 4E-BP1; eIF4E-binding protein-1; CDK; cyclin-dependent kinase; eIF4E; eukaryotic initiation factor 4E; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; S6K; S6 kinase; TGF-β; transforming growth factor-β;
RACK1-mediated translation control promotes liver fibrogenesis
Keywords: Hepatic stellate cells; RACK1; eIF4E; Liver fibrosis;
eIF4E-mediated translational control of cancer incidence
Keywords: Translation; eIF4E; Cancer incidence; Anticancer defense; Cancer therapy;
MicroRNA-7: A miRNA with expanding roles in development and disease
Keywords: ACK1; activated CDC42 kinase 1; BASP1; brain abundant, membrane attached signal protein 1; c-Myc; v-Myc avian myelocytomatosis viral oncogene homolog; CD57; cluster of differentiation 57; CD44; cluster of differentiation 44; ciRS-7; circular RNA sponge fo
Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down's syndrome
Keywords: 4EBPs; eIF4E-binding proteins; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BDNF; brain-derived neurotrophic factor; CHX; cycloheximide; DG; dentate gyrus; DS; Down's syndrome; eIF4E; eukaryotic translation initiation factor 4E; ERK; extra
Early growth response-1 facilitates enterovirus 71 replication by direct binding to the viral genome RNA
Keywords: 3â²UTR; 3â²-untranslated region; 5â²UTR; 5â²-untranslated region; CNS; central nervous system; Co-IP; co-immunoprecipitation; CPE; cytopathogenic effect; DMEM; Dulbecco's modified Eagle's medium; EGR1; early growth response-1; eIF4E; eukaryotic initia
Discovery of 4-(dihydropyridinon-3-yl)amino-5-methylthieno[2,3-d]pyrimidine derivatives as potent Mnk inhibitors: synthesis, structure-activity relationship analysis and biological evaluation
Keywords: eIF4E; Mnk; Inhibitor; Structure-activity relationship; Thieno[2,3-d]pyrimidine derivatives;
eIF4E/Fmr1 double mutant mice display cognitive impairment in addition to ASD-like behaviors
Keywords: Autism spectrum disorders; Protein synthesis; eIF4E; Fragile X syndrome; Cognition; Genetic models; Rodent behavior;
Requirement of the eukaryotic translation initiation factor 4F complex in hepatitis E virus replication
Keywords: Hepatitis E virus; Eukaryotic translation initiation factor 4F complex; eIF4E-binding protein 1; Ribavirin; IFN-α; HEV; hepatitis E virus; eIF4F; eukaryotic translation initiation factor 4F; eIF4A; eukaryotic initiation translation factor 4A; eIF4G; euka
MYC and metabolism on the path to cancer
Keywords: 2-DG; 2-deoxyglucose; 4E-BP; eIF4E-binding protein; 5,10-methylene THF; 5,10-methylenetetrahydrofolate; ACC; acetyl-CoA carboxylase; ACLY; ATP-citrate lyase; AMPK; AMP-activated protein kinase; ATP; adenosine triphosphate; ChIP-seq; chromatin immunoprecip
PRMT5 is essential for the eIF4E-mediated 5â²-cap dependent translation
Keywords: Protein arginine methyltransferase 5; 5â²-Cap dependent translation; eIF4E; c-Myc; Cyclin D1;
Dual mTORC1/2 inhibition in a preclinical xenograft tumor model of endometrial cancer
Keywords: mTOR pathway; Endometrial cancer; Rapamycin; Preclinical study; Translational regulation; eIF4E; Akt; therapeutics;