The putative tumor suppressor microRNA-497 modulates gastric cancer cell proliferation and invasion by repressing eIF4E
Keywords: MiR-497; eIF4E; Gastric cancer;
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Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells
Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; AMPK; 5â²-AMP-activated protein kinase; APC; adenomatous polyposis coli; CK1; casein kinase 1; CM; conditioned medium; eIF4E; eukaryotic initiation factor 4E; GSK3β; glycogen synthase kinase-3β
Evolution of plant eukaryotic initiation factor 4E (eIF4E) and potyvirus genome-linked protein (VPg): A game of mirrors impacting resistance spectrum and durability
Keywords: Potyvirus; Capsicum annuum; Host resistance; Host-parasite coevolution; eIF4E; VPg;
Activation of ERK by sodium tungstate induces protein synthesis and prevents protein degradation in rat L6 myotubes
Keywords: DEX; dexamethasone; ERK; extracellular signal-regulated kinases 1 and 2; eIF4E; eukaryotic initiation factor E; 4E-BP1; eIF4E-binding protein 1; FoxO; Forkhead box O Family of Transcription Factors; IGF-I; Insulin Growth Factor I; MTOR; mechanistic target
p70S6 kinase is a critical node that integrates HER-family and PI3 kinase signaling networks
Keywords: p70S6K; p70S6 kinase; PI3K; phosphoinositide-3-kinase; RPPA; Reverse Phase Protein Array; mTOR; mammalian target of rapamycin; MAPK; mitogen activated protein kinase; EGFR; epidermal growth factor receptor; NSCLC; non-small cell lung cancer; RTK; receptor
Disialoganglioside GD3-synthase over expression inhibits survival and angiogenesis of pancreatic cancer cells through cell cycle arrest at S-phase and disruption of integrin-β1-mediated anchorage
Keywords: Angiogenesis; GD3; Integrin-β1; Pancreatic ductal adenocarcinoma; S phase; B-MAA; biotinylated-Maackia amurensis lectin; b-FGF; basic fibroblast growth factor; B-SNA; biotinylated-Sambucus nigra lectin; DAPI; 4â²,6-diamidino-2-phenylindole; ECM; extra-c
Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway
Keywords: PI3K pathway; Targeted therapy; Predictive biomarkers; 4EBP1; 4E-binding protein 1; AKT; protein kinase-B; AMPK; AMP-activated protein kinase; COSMIC; Catalogue of Somatic Mutations in Cancer; eIF4E; eukaryotic initiation factor 4E; ERK; extracellular-sig
Inhibition of S6 kinase suppresses the apoptotic effect of eIF4E ablation by inducing TGF-β-dependent G1 cell cycle arrest
Keywords: mTOR; eIF4E; Apoptosis; TGF-β; Cell cycle;
Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a)
Keywords: Mnk; mTORC1; Rapamycin; eIF4E;
Solution-based approach to study binding to the eIF4E cap-binding site using CD spectroscopy
Keywords: CD spectroscopy; Exciton coupling; eIF4E; Protein refolding;
Prion formation correlates with activation of translation-regulating protein 4E-BP and neuronal transcription factor Elk1
Keywords: PrPC; normal cellular prion protein; PrPSc; disease-associated prion protein; GT1-1 cells; immortalized hypothalamic gonadotropin-releasing hormone neurons; BDNF; brain-derived neurotrophic factor; MEK; mitogen-activated protein kinase kinase; ERK; extrac
HPV E6 induces eIF4E transcription to promote the proliferation and migration of cervical cancer
Keywords: eIF4E; Cervical cancer; Human papillomavirus; HPV; E6;
Stress granules form in Brachionus manjavacas (Rotifera) in response to a variety of stressors
Keywords: SGs; TIA-1; eIF3B; eIF4E; RNA granules;
Translation of viral mRNAs that do not require eIF4E is blocked by the inhibitor 4EGI-1
Keywords: IRES translation; 4EGI-1; IRES inhibitors; Picornavirus translation; eIF4E;
Intrahost mechanisms governing emergence of resistance-breaking variants of Potato virus Y
Keywords: Cell-to-cell movement; Clonal interference; eIF4E; Hidden virulence; Potyvirus; Quasispecies; Random drift; Recessive resistance; Replicative fidelity; Selection
In vivo study of breast carcinoma radiosensitization by targeting eIF4E
Keywords: eIF4E; pSecX-t4EBP1; Breast cancer; Xenograft; Radiosensitization;
The “closed loop model” in controlling mRNA translation during development
Keywords: Translation initiation factors; eIF4E; 4E-BP1; Translational regulation; Tarm animals
Hydrogen peroxide induces stress granule formation independent of eIF2α phosphorylation
Keywords: Oxidative stress; RNA; Stress granules; Translation; eIF4E; eIF2;
4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2
Keywords: 4E-BP3; eIF4E; RPA2; mRNA export;
Cap binding-independent recruitment of eIF4E to cytoplasmic foci
Keywords: eIF4E; P-body; Cap-binding; Stress granule;
The involvement of eukaryotic translation initiation factor 4E in extravillous trophoblast cell function
Keywords: Placenta; EVT; Differentiation; eIF4E;
Research reportPost-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: Regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation
Keywords: BDNF; brain-derived neurotrophic factor; CMS; chronic mild stress; CPEB; cytoplasmic polyadenylation element-binding protein; eEF2; eukaryotic elongation factor 2; eIF4E; eukaryotic initiation factor 4E; HFS; high-frequency stimulation; LTP; long-term pot
Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells
Keywords: Chemoprevention; Colon Cancer; Oncogene; Tumor Suppressor; ACC; acetyl-CoA carboxylase; ADP; adenosine diphosphate; AMPK; adenosine monophosphate-activated protein kinase; ATP; adenosine triphosphate; CRC; colorectal cancer; eIF4E; eukaryotic translatio
Identification and function of the second eIF4E-binding region in N-terminal domain of eIF4G: Comparison with eIF4E-binding protein
Keywords: 4E-BP; eIF4E-binding protein; CD; circular dichroism; DTT; dithiothreitol; eIF4E; eukaryotic initiation factor 4E; HEPES; 2-[4-(2-hydroxyethyl)-1-piperazinyl] ethanesulfonic acid; ITC; isothermal titration calorimetry; MD; molecular dynamics; m7GTP; 7-met
Ago2/miRISC-mediated inhibition of CBP80/20-dependent translation and thereby abrogation of nonsense-mediated mRNA decay require the cap-associating activity of Ago2
Keywords: Ago2; MicroRNA; NMD; CBP80/20; eIF4E
The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder
Keywords: MDD; major depressive disorder; PFC; prefrontal cortex; NMDA; N-methyl-d-aspartate; NR2A; NMDA receptor subunit 2A; NR2B; NMDA receptor subunit 2B; mGluR5; metabotropic glutamate receptor subtype 5; PSD-95; postsynaptic density-95Â kDa; mTOR; mammalian ta
Deregulation of cap-dependent mRNA translation increases tumour radiosensitivity through reduction of the hypoxic fraction
Keywords: eIF4E; mTOR; Hypoxia; Necrosis; Irradiation;
Mutational analysis of the EMCV 2A protein identifies a nuclear localization signal and an eIF4E binding site
Keywords: Encephalomyocarditis virus; 2A protein; eIF4E; Internal ribosome entry site; Nuclear localization signal;
The four trypanosomatid eIF4E homologues fall into two separate groups, with distinct features in primary sequence and biological properties
Keywords: Translation; eIF4E; eIF4G; Trypanosomatid; Leishmania;
So similar, yet so different: Selective translation of capped and polyadenylated viral mRNAs in the influenza virus infected cell
Keywords: Influenza virus; Translation; NS1; eIF4E;
Lack of compensatory pAKT activation and eIF4E phosphorylation of lymphoma cells towards mTOR inhibitor, RAD001
Keywords: RAD001; mTOR; AKT; eIF4E; Cyclin D3; c-Myc; IRS-1;
Simple construction of chimeric hairpin RNA for virus resistance in plants
Keywords: Chimeric hairpin RNA; OE-PCR; Virus resistance; PRSV; eIF4E; eIFiso4E
Prognostic significance of expression of eukaryotic initiation factor 4E and 4E binding protein 1 in patients with pathological stage I invasive lung adenocarcinoma
Keywords: Translational control; eIF4E; eIF4E binding protein 1; Prognosis; Lung adenocarcinoma
JNK inhibition arrests cotranslational degradation
Keywords: eIF2; eIF4E; Fibronectin; Spreading; Proteasome; Polysomes;
Interaction of Pdcd4 with eIF4E inhibits the metastatic potential of hepatocellular carcinoma
Keywords: PDCD4; EIF4E; Oxidative stress
Sox2 is translationally activated by eukaryotic initiation factor 4E in human glioma-initiating cells
Keywords: Glioma; Glioma-initiating cell; Sox2; Self-renewal; eIF4E
Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMP
Keywords: eIF4E; Translation initiation; Anticancer; Antifibrotic; CoMFA; CoMSIABn7-GMP, N7-benzylated guanosine monophosphate; GDP, Guanosine diphosphate; GTP, Guanosine triphosphate; EWG, Electron withdrawing group; EDG, Electron donating group; ESI-MS, Electrosp
Avian reovirus influences phosphorylation of several factors involved in host protein translation including eukaryotic translation elongation factor 2 (eEF2) in Vero cells
Keywords: Avian reovirus; eEF2; eIF4E; eIF-4G
Predictive Value of eIF4E Reduction After Neoadjuvant Therapy in Breast Cancer
Keywords: eIF4E; neoadjuvant therapy; prognostic marker; therapeutic marker; cancer response
Rapamycin increases the p53/MDM2 protein ratio and p53-dependent apoptosis by translational inhibition of mdm2 in cancer cells
Keywords: MDM2; p53; Rapamycin; eIF4E; Translational control
Ribavirin targets eIF4E dependent Akt survival signaling
Keywords: eIF4E; Akt; m7G cap; Ribavirin; RNA regulon; NBS1
Half pint couples transcription and splicing of eIF4E-1,2 gene during fly development
Keywords: Alternative splicing; eIF4E; Half pint; Transcription; Translation
Eukaryotic initiation factor 4E
Keywords: Translation; eIF4E; mRNA export; Calicivirus
Ectopic expression of eIF4E-transporter triggers the movement of eIF4E into P-bodies, inhibiting steady-state translation but not the pioneer round of translation
Keywords: eIF4E-T; eIF4E; CBP80; The pioneer round of translation; Steady-state translation; Nonsense-mediated mRNA decay; Processing bodies; Internal ribosome entry site
eIF4E-Targeted Suicide Gene Therapy in a Minimal Residual Mouse Model for Metastatic Soft-Tissue Head and Neck Squamous Cell Carcinoma Improves Disease-Free Survival
Keywords: cytoreductive; eIF4E; adenovirus; squamous cell carcinoma; head and neck cancer
Expression, purification and characterization of recombinant mouse translation initiation factor eIF4E as a dihydrofolate reductase (DHFR) fusion protein
Keywords: Translational initiation factor; eIF4E; Fluorescence quenching; DHFR
Complementary functions of two recessive R-genes determine resistance durability of tobacco ‘Virgin A Mutant’ (VAM) to Potato virus Y
Keywords: Picornavirus; Genome-linked protein; VPg; eIF4E; Gene pyramiding; Pepper pvr2 gene; Pathogenesis; Tolerance; Cytoplasmic inheritance; Protoplast printing
Pondering the puzzle of PML (promyelocytic leukemia) nuclear bodies: Can we fit the pieces together using an RNA regulon?
Keywords: PML; ND10; POD; eIF4E; RNA regulon/operon
Significance of eIF4E expression in skin squamous cell carcinoma
Keywords: eIF4E; Initiation translation; Squamous cell carcinoma;
Coordinated and selective recruitment of eIF4E and eIF4G factors for potyvirus infection in Arabidopsis thaliana
Keywords: Recessive resistance; eIF4E; eIF4G; Plant potyvirus