In vivo study of breast carcinoma radiosensitization by targeting eIF4E

► eIF4E is associated with the formation and progression for breast cancer. ► pSecX-t4EBP1 can downregulated the expression of eIF4E in direct binding. ► We transfected pSecX-t4EBP1 into a mouse xenograft model. ► It can significantly inhibit tumor growth and enhance the radiosensitivity. ► The possible mechanism is downregulation of HIF-1α expression.