کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9889949 | 1539994 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
DAP-kinase-Protector or enemy in apoptotic cell death
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
Death-associated protein (DAP)-kinase, a member of a novel subfamily of pro-apoptotic serine/threonine kinases, was recently identified as a new tumor suppressor gene with multiple functions in programmed cell death. This 160-kDa protein consists of different interaction domains that enable it to participate in seemingly contradictory pathways such as elimination of premalignant cells or cytoprotection in cellular homoeostasis. DAP-kinase is frequently inactivated by aberrant promoter methylation in many cancer types, and its expression was shown to be a useful molecular marker for cancer prognosis. Moreover, DAP-kinase is considered a regulator of neuronal apoptosis. Future investigations should allow for the evaluation of DAP-kinase as a potential target for both pro- and anti-apoptotic therapeutic interventions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 37, Issue 9, September 2005, Pages 1763-1767
Journal: The International Journal of Biochemistry & Cell Biology - Volume 37, Issue 9, September 2005, Pages 1763-1767
نویسندگان
Regine Schneider-Stock, Albert Roessner, Oliver Ullrich,