کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9891550 | 1540767 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biotin - a regulator of gene expression
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
The role of biotin as the prosthetic group of the four biotin-dependent carboxylases in higher organisms is well recognized. Based on the roles of these carboxylases in metabolism, the requirement of biotin for cell viability, growth and differentiation was established. Biotin seems to have a role in cell functions other than as the prosthetic group of biotin enzymes. Biotin seems to influence processes such as the proliferation of the mesenchyme, spermatogenesis and song-bird vocalization. A direct effect of biotin, at the transcriptional level, has been shown for the key enzymes of glucose metabolism. Glucokinase, a key glycolytic enzyme, and phosphoenolpyruvate carboxykinase (PEPCK), a key gluconeogenic enzyme, are regulated in opposite directions by biotin in a manner similar to the action of insulin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 16, Issue 7, July 2005, Pages 419-423
Journal: The Journal of Nutritional Biochemistry - Volume 16, Issue 7, July 2005, Pages 419-423
نویسندگان
Krishnamurti Dakshinamurti,