کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9894344 | 1542454 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of the adrenomedullin gene in adipose tissue
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کلمات کلیدی
BATCGRPVSMCRAMPSVECob/ob mice - mob / ob موشadrenomedullin - آدرنومدولینVascular smooth muscle cells - سلول های عضلانی صاف عروقیVascular endothelial cells - سلولهای اندوتلیال عروقیObesity - مرض چاقیReceptor-activity-modifying protein - پروتئین تغییر دهنده گیرندهcalcitonin gene-related peptide - پپتید مرتبط با ژن کلسی تونینFat - چربی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Adrenomedullin (AM) is a potent vasodilating peptide originally isolated from human pheochromocytoma cells. This report concerns the expression and secretion of AM from adipose tissue. Northern blot analysis demonstrated marked expression of AM mRNA in mouse adipose tissue. Expression levels in adipose tissues were 2.5-3.2 times higher than in the kidney. AM mRNA level in mature adipocytes was 7.3 times higher than in the stroma-vascular fraction of adipose tissue. In mature adipocyte culture, time-dependent increase of AM peptide concentration in the culture medium was detected. AM expression was also detected in human subcutaneous adipose tissue. Adipose AM expression significantly increased in obesity mouse model, high-fat diet fed mice and ob/ob mice. These results suggest that adipose tissue, especially mature adipocytes, is major source of AM in the body, and that adipocyte-derived AM plays a pathophysiological role in obesity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Peptides - Volume 132, Issues 1â3, 15 December 2005, Pages 17-22
Journal: Regulatory Peptides - Volume 132, Issues 1â3, 15 December 2005, Pages 17-22
نویسندگان
Takuo Nambu, Hiroshi Arai, Yasato Komatsu, Akihiro Yasoda, Kenji Moriyama, Naotetsu Kanamoto, Hiroshi Itoh, Kazuwa Nakao,