Functional characterisation of tachykinin receptors in the circular muscle layer of the mouse ileum

Tachykinins mediate NANC contractions to EFS in the mouse small intestine. Endogenously released tachykinins activate mainly NK1 receptors, located on cholinergic nerves and smooth muscle cells and, to a lesser degree, NK2 and NK3 receptors, most likely located presynaptically.