کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9894448 1542459 2005 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
HLDF-6 peptide affects behavioral reactions and organism functions dependent on androgen hormones in normal and castrated male mice
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
HLDF-6 peptide affects behavioral reactions and organism functions dependent on androgen hormones in normal and castrated male mice
چکیده انگلیسی
HLDF-6 increased testosterone level (1.5- to 2-fold) both in sham-operated and castrated animals. Sexual activity and pain sensitivity, which are strongly reduced in castrates, were completely or partially recovered by HLDF-6. At the same time, the peptide caused some effects similar to castration in sham-operated animals: aggression and locomotor activity were decreased; oral grooming was prolonged. Morphological studies of accessory sex glands showed that HLDF-6 partially normalizes the morphology and functional activity of seminal vesicles in castrates, but it does not prevent castration-induced apoptosis of prostate epithelial cells. Based on these observations, we can assume that HLDF-6 peptide displays at least two effects on androgen hormones metabolism in males: it stimulates testosterone biosynthesis by both testes and adrenals and simultaneously inhibits its conversion to dihydrotestosterone (DHT), most probably by diminution of 5α-reductase isoform 1 mRNA expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Peptides - Volume 127, Issues 1–3, 15 April 2005, Pages 111-121
نویسندگان
, , , , , , , , ,