کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9914858 | 1551012 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Steroid receptor coactivator-3, a homolog of Taiman that controls cell migration in the Drosophila ovary, regulates migration of human ovarian cancer cells
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کلمات کلیدی
FAKIGF-1REGF-RSRC-3Steroid receptor coactivator-3short interfering RNA - RNA تداخل کوتاهsiRNA - siRNAOvarian cancer - سرطان تخمدانCell migration - مهاجرت سلولیAntibody - پادتَن یا آنتیبادیfocal adhesion kinase - کیناز چسبندگی کانونیsteroid receptor coactivator - گیرنده استروئید گیرندهEstrogen receptor - گیرنده استروژنInsulin-like growth factor-1 receptor - گیرنده فاکتور 1 رشد انسولینEpidermal growth factor receptor - گیرنده فاکتور رشد اپیدرمال
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
Border cell migration is a process that occurs during Drosophila ovarian development in which cells derived from a simple epithelium migrate and invade neighboring tissue. This process resembles the behavior of cancerous cells that derive from the simple epithelium of the human ovary. One important regulator of border cell migration is Taiman, a homolog of steroid receptor coactivator-3 (SRC-3). Because increasing evidence indicates that similarities exist between the molecular control of migration of border cells and of cancer cells, we investigated whether SRC-3 controls ovarian cancer cell migration. Little or no SRC-3 expression was detected in normal ovarian surface epithelium, ovarian cysts and borderline ovarian tumors that lack stromal invasion. In contrast, SRC-3 was abundantly expressed in high-grade ovarian carcinomas. Inhibiting SRC-3 expression in ovarian cancer cells markedly reduced cell spreading and migration, and altered intracellular localization of focal adhesion kinase. This inhibitory effect on cell migration was independent of the estrogen receptor (ER) status of the cells. These studies reveal a novel role for SRC-3 in ovarian cancer progression by promoting cell migration, independently of its role in estrogen receptor signaling.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 245, Issues 1â2, 21 December 2005, Pages 77-85
Journal: Molecular and Cellular Endocrinology - Volume 245, Issues 1â2, 21 December 2005, Pages 77-85
نویسندگان
Hiroyuki Yoshida, Jinsong Liu, Shaija Samuel, Wenjun Cheng, Daniel Rosen, Honami Naora,